Abstract
INTRODUCTION: Consumption of Chinese Herbal Medicine (CHMs) have escalated globally. They are preferred treatment for minor diseases or disorders. In Malaysia, CHMs are common home remedies during pregnancy and postpartum. Angelicae Sinesis (Danggui) is a staple CHMs during postpartum for purpose of nourishing blood and resolving stasis. Concerns are raised over possible heavy metals toxicity. Thus, this study aims to determine danggui consumption among postpartum mothers and its heavy metals concentrations, namely Lead (Pb), Cadmium (Cd), Arsenic (As) and Chromium (Cr). METHODS: This is a cross sectional questionnaire study involving 147 postpartum mothers. Samples were collected from nine districts in Kuala Lumpur (Segambut, Seputeh, Cheras, Kepong, Bandar Tun Razak, Titiwangsa, Setiawangsa, Batu and Lembah Pantai). Then, they were extracted using microwave digester and analysed using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) in triplicates; totalling 27 samples. Non-carcinogenic health risks for herbal medicine consumption were calculated using Hazard Quotient (HQ). RESULTS: Danggui was consumed by 10.1% of mothers (n=15). Among them, incidence of jaundice was 73.3% and need for phototherapy was 46.7%. Heavy metals contaminations were found in the decreasing order of Cr>As>Pb>Cd with median(interquartile) of 3996.3 (2805.6) ?g/kg, 128.3(56.7), 98.6(99.1) and 37.0(35.0) respectively. Only As had significant non-carcinogenic health risks in worst case scenario with HQ>1 eliciting possible adverse health effect. As is a confirmed human carcinogen and can induce skin, lung and bladder cancer. CONCLUSION: Alarming concentrations of heavy metals were quantified in danggui warranting for further investigation to safeguard health of postpartum mothers.
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@proceedings{APCPH-2019-60,
title = {Heavy Metals in Angelicae Sinesis (Danggui) Consumed by Postpartum Mothers and Its Health Risk},
author = {Eugenie Tan Sin Sing and Normina Ahmad Bustami and Ho Yu Bin and Tan Chung Keat and Ahmad Zaharin Aris},
year = {2019},
date = {2019-07-22},
urldate = {2019-07-22},
journal = {6th Asia-Pacific Conference on Public Health 2019 Proceedings},
issue = {6},
abstract = {INTRODUCTION: Consumption of Chinese Herbal Medicine (CHMs) have escalated globally. They are preferred treatment for minor diseases or disorders. In Malaysia, CHMs are common home remedies during pregnancy and postpartum. Angelicae Sinesis (Danggui) is a staple CHMs during postpartum for purpose of nourishing blood and resolving stasis. Concerns are raised over possible heavy metals toxicity. Thus, this study aims to determine danggui consumption among postpartum mothers and its heavy metals concentrations, namely Lead (Pb), Cadmium (Cd), Arsenic (As) and Chromium (Cr). METHODS: This is a cross sectional questionnaire study involving 147 postpartum mothers. Samples were collected from nine districts in Kuala Lumpur (Segambut, Seputeh, Cheras, Kepong, Bandar Tun Razak, Titiwangsa, Setiawangsa, Batu and Lembah Pantai). Then, they were extracted using microwave digester and analysed using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) in triplicates; totalling 27 samples. Non-carcinogenic health risks for herbal medicine consumption were calculated using Hazard Quotient (HQ). RESULTS: Danggui was consumed by 10.1% of mothers (n=15). Among them, incidence of jaundice was 73.3% and need for phototherapy was 46.7%. Heavy metals contaminations were found in the decreasing order of Cr\>As\>Pb\>Cd with median(interquartile) of 3996.3 (2805.6) ?g/kg, 128.3(56.7), 98.6(99.1) and 37.0(35.0) respectively. Only As had significant non-carcinogenic health risks in worst case scenario with HQ\>1 eliciting possible adverse health effect. As is a confirmed human carcinogen and can induce skin, lung and bladder cancer. CONCLUSION: Alarming concentrations of heavy metals were quantified in danggui warranting for further investigation to safeguard health of postpartum mothers.},
note = {Type: ORAL PRESENTATION; Organisation: Faculty of Medicine and Health Science, UCSI University, Kuala Lumpur, Malaysia, Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Faculty of Environmental Studies, Universiti Putra Malaysia, Selangor, Malaysia},
keywords = {Angelicae Sinesis (Danggui), heavy metals exposure, non-carcinogenic health risk, postpartum mothers},
pubstate = {published},
tppubtype = {proceedings}
}