Abstract
INTRODUCTION: To assess the effect of hormone replacement therapy (HRT) on the occurrence of cancer in Korean postmenopausal women. METHODS: We used cohort dataset of Health examination DB from the National Health Insurance Service, which included 514,866 subjects from 2002 to 2013. We chose women aged 40-69 between 2002 and 2003 (n=168,043). Follow-up cancer diagnosis was carried out up until 2013. We used a nested case-control design because both groups have to match the exposure period. To adjust for any potential confounders, a propensity score matched analysis was carried out using the logistic regression model and 1:3 propensity-matched groups We used the Cox proportional regression model to calculate the hazard ratio (HR). RESULTS: There were 9,764 cases of HRT and 27,818 cases of never user between 2002 and 2003. During 11-year total follow-up period, 3,515 (9.35%) cases of primary cancer were identified. On the basis of survival analysis, we adopted the Cox proportional hazards model and found that HRT was negative associated with cancer occurrence (HR: 0.80, 95%CI: 0.73, 0.88
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@proceedings{APCPH-2019-46,
title = {Effect of Hormone Replacement Therapy on Incidence of Four Major Cancers of Postmenopausal Women in Korea},
author = {Minjin Kang},
year = {2019},
date = {2019-07-22},
urldate = {2019-07-22},
journal = {6th Asia-Pacific Conference on Public Health 2019 Proceedings},
issue = {6},
abstract = {INTRODUCTION: To assess the effect of hormone replacement therapy (HRT) on the occurrence of cancer in Korean postmenopausal women. METHODS: We used cohort dataset of Health examination DB from the National Health Insurance Service, which included 514,866 subjects from 2002 to 2013. We chose women aged 40-69 between 2002 and 2003 (n=168,043). Follow-up cancer diagnosis was carried out up until 2013. We used a nested case-control design because both groups have to match the exposure period. To adjust for any potential confounders, a propensity score matched analysis was carried out using the logistic regression model and 1:3 propensity-matched groups We used the Cox proportional regression model to calculate the hazard ratio (HR). RESULTS: There were 9,764 cases of HRT and 27,818 cases of never user between 2002 and 2003. During 11-year total follow-up period, 3,515 (9.35%) cases of primary cancer were identified. On the basis of survival analysis, we adopted the Cox proportional hazards model and found that HRT was negative associated with cancer occurrence (HR: 0.80, 95%CI: 0.73, 0.88},
note = {Type: ORAL PRESENTATION; Organisation: NHIS Ilsan Hospital},
keywords = {cancer, hormone replacement therapy, tibolone},
pubstate = {published},
tppubtype = {proceedings}
}