Abstract
BACKGROUND: High red meat intake, obesity and low level of zinc have been reportedly associated with colorectal cancer (CRC) risk. The aim of the present study was to explore the interaction between serum zinc with red meat intake and obesity on CRC risk. METHODS: Patients with CRC and the controls were recruited for the information on red meat intake, body mass index and blood sample. The serum samples of 204 patients of CRC and controls were analysed for Al, Zn and Co using Inductively Coupled Plasma Mass Spectrometer (ICPMS). Multiplicative interaction was assessed through a cross-product interaction term in a multiple logistic regression model. The presence of addictive interaction was evaluated by calculation of the relative excess risk due to interaction (RERI) and attributable proportion due to interaction (AP). RESULTS: The odds ratios (ORs) of the serum zinc-red meat intake product term on a multiplicative scale in the univariate and multivariate models were 5.49 (95% confidence interval, 95%CI: 3.48, 8.65) and 0.53 (95%CI: 0.04, 7.34), respectively. There was also evidence for interaction on an additive scale; the RERI and AP in the univariate model were 0.27 (95%CI: 0.03, 0.50) and 0.92 (95%CI 0.83, 1.01), respectively. After adjusting for the potential confounders, the value of RERI 0.22(95%CI: -0.13, 0.57) and AP 0.95 (5%CI: 0.89, 1.03). While for obesity factor, the serum zinc-obesity product term on multiplicative scale were 3.68 (95%CI: 1.41, 9.57) in univariate model and 4.55 (95%CI: 0.33, 62.85) in multivariate model. The value of addictive scale, RERI; 0.07(95%CI: -0.02 to 0.15), AP; 0.57(95%CI: 0.18, 0.97) in univariate model and RERI; 0.05(95%CI: -0.05, 0.15) and AP; 0.65 (95%CI: 0.04, 1.26) in multivariate model. CONCLUSION: Serum zinc and red meat intake interact strongly and synergistically influence the risk of CRC compare to obesity factor. Further investigations with big sample size are necessary for confirming this additive interaction.
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@proceedings{APCPH-2019-70,
title = {Joint Effects of Serum Zinc with Red Meat Intake and Obesity on the Risk of Colorectal Cancer: A Case-Control Study},
author = {Azmawati Mohammed Nawi},
year = {2019},
date = {2019-07-22},
urldate = {2019-07-22},
journal = {6th Asia-Pacific Conference on Public Health 2019 Proceedings},
issue = {6},
abstract = {BACKGROUND: High red meat intake, obesity and low level of zinc have been reportedly associated with colorectal cancer (CRC) risk. The aim of the present study was to explore the interaction between serum zinc with red meat intake and obesity on CRC risk. METHODS: Patients with CRC and the controls were recruited for the information on red meat intake, body mass index and blood sample. The serum samples of 204 patients of CRC and controls were analysed for Al, Zn and Co using Inductively Coupled Plasma Mass Spectrometer (ICPMS). Multiplicative interaction was assessed through a cross-product interaction term in a multiple logistic regression model. The presence of addictive interaction was evaluated by calculation of the relative excess risk due to interaction (RERI) and attributable proportion due to interaction (AP). RESULTS: The odds ratios (ORs) of the serum zinc-red meat intake product term on a multiplicative scale in the univariate and multivariate models were 5.49 (95% confidence interval, 95%CI: 3.48, 8.65) and 0.53 (95%CI: 0.04, 7.34), respectively. There was also evidence for interaction on an additive scale; the RERI and AP in the univariate model were 0.27 (95%CI: 0.03, 0.50) and 0.92 (95%CI 0.83, 1.01), respectively. After adjusting for the potential confounders, the value of RERI 0.22(95%CI: -0.13, 0.57) and AP 0.95 (5%CI: 0.89, 1.03). While for obesity factor, the serum zinc-obesity product term on multiplicative scale were 3.68 (95%CI: 1.41, 9.57) in univariate model and 4.55 (95%CI: 0.33, 62.85) in multivariate model. The value of addictive scale, RERI; 0.07(95%CI: -0.02 to 0.15), AP; 0.57(95%CI: 0.18, 0.97) in univariate model and RERI; 0.05(95%CI: -0.05, 0.15) and AP; 0.65 (95%CI: 0.04, 1.26) in multivariate model. CONCLUSION: Serum zinc and red meat intake interact strongly and synergistically influence the risk of CRC compare to obesity factor. Further investigations with big sample size are necessary for confirming this additive interaction.},
note = {Type: ORAL PRESENTATION; Organisation: Universiti Kebangsaan Malaysia},
keywords = {CRC, interaction, obese, red meat, Trace element},
pubstate = {published},
tppubtype = {proceedings}
}