Abstract
INTRODUCTION: Peripheral arterial disease (PAD) is a systemic atherosclerosis and is associated with increased cardiovascular morbidity and mortality. As chronic pesticides exposure may potentiate the risk of atherosclerosis, this study examined the relationship between occupational pesticides exposure and the development of PAD among paddy farmers. METHODS: A total of 193 paddy farmers who had direct exposure to pesticides and 196 inhabitants who were not directly exposed to pesticides in Northwest Selangor were examined for ABI, blood glucose and lipid profile. Information on pesticides usage and work practice were obtained using a validated questionnaire. RESULTS: The mean ABI of this study population was 1.21 (SD 0.17). There were 3.1% (95%CI 1.5, 5.1) and 15.4% (95%CI 12.1, 19.0) subjects with low and high ABI respectively. There was significant difference in the ABI reading between directly exposed group and non-directly exposed group (p<0.001). After controlling for confounders in multiple logistic regression model, those with low ABI were more likely to have older age (OR 1.06), higher glucose (OR 2.51), lower HDL-cholesterol (OR 2.34), and higher cumulative exposure to Chlorpyrifos (OR 2.15). While respondents with high ABI have longer duration of working in paddy fields (OR1.07), higher triglycerides (OR 1.65), higher cumulative exposure to Methomyl (OR 2.17) and Paraquat (OR 2.13). DISCUSSION: Apart from traditional vascular risk factors, chronic exposure to pesticides may contribute to an increase risk of PAD. Early identification of pesticides exposure levels and early PAD detection are useful in populations that are more susceptible to adverse effects of pesticides.
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@proceedings{APCPH-2019-291,
title = {The Effect of Occupational Pesticides Exposure On Ankle Brachial Index Among Paddy Farmers in Northwest Selangor, Malaysia},
author = {Azizah Wahab and Noor Hassim Ismail and Rozita Hod},
year = {2019},
date = {2019-07-22},
urldate = {2019-07-22},
journal = {6th Asia-Pacific Conference on Public Health 2019 Proceedings},
issue = {6},
abstract = {INTRODUCTION: Peripheral arterial disease (PAD) is a systemic atherosclerosis and is associated with increased cardiovascular morbidity and mortality. As chronic pesticides exposure may potentiate the risk of atherosclerosis, this study examined the relationship between occupational pesticides exposure and the development of PAD among paddy farmers. METHODS: A total of 193 paddy farmers who had direct exposure to pesticides and 196 inhabitants who were not directly exposed to pesticides in Northwest Selangor were examined for ABI, blood glucose and lipid profile. Information on pesticides usage and work practice were obtained using a validated questionnaire. RESULTS: The mean ABI of this study population was 1.21 (SD 0.17). There were 3.1% (95%CI 1.5, 5.1) and 15.4% (95%CI 12.1, 19.0) subjects with low and high ABI respectively. There was significant difference in the ABI reading between directly exposed group and non-directly exposed group (p\<0.001). After controlling for confounders in multiple logistic regression model, those with low ABI were more likely to have older age (OR 1.06), higher glucose (OR 2.51), lower HDL-cholesterol (OR 2.34), and higher cumulative exposure to Chlorpyrifos (OR 2.15). While respondents with high ABI have longer duration of working in paddy fields (OR1.07), higher triglycerides (OR 1.65), higher cumulative exposure to Methomyl (OR 2.17) and Paraquat (OR 2.13). DISCUSSION: Apart from traditional vascular risk factors, chronic exposure to pesticides may contribute to an increase risk of PAD. Early identification of pesticides exposure levels and early PAD detection are useful in populations that are more susceptible to adverse effects of pesticides.},
note = {Type: POSTER PRESENTATION; Organisation: Cheras District Health Office, Federal Territory of Kuala Lumpur, Malaysia, Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Malaysia},
keywords = {ABI, Northwest Selangor, paddy farmer, pesticide},
pubstate = {published},
tppubtype = {proceedings}
}